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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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Dimethyl malonate (CAS 108-59-8) is a competitive inhibitor of succinate dehydrogenase (SDH) an essential enzyme in the mitochondrial tricarboxylic acid (TCA) cycle This compound effectively crosses the blood-brain barrier and is hydrolyzed within brain tissue to yield malonic acid which modulates SDH activity and impairs mitochondrial respiration By altering TCA cycle metabolism dimethyl malonate has been shown to reduce neuronal apoptosis It is frequently employed in studies investigating mitochondrial dysfunction mechanisms of neuronal cell death and the pathophysiology of neurodegenerative diseases serving as a useful tool for establishing disease models and exploring potential therapeutic interventions
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Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is a flavonol glycoside that possesses antioxidant activity. In a cell-free environment, it exhibits excellent antioxidant ability and protects pBR322 DNA from oxidative damage.
Exhibits excellent antioxidant ability in a cell-free environment.
Protects pBR322 DNA from oxidative damage.
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Malonic acid is a small-molecule dicarboxylic acid It is commonly used to facilitate the cross-linking of polysaccharide molecules such as corn starch and potato starch by forming covalent linkages via its two carboxyl groups Malonic acid acts primarily through condensation or esterification reactions to increase intermolecular connectivity and modulate the mechanical properties of biopolymer matrices Based on these properties malonic acid holds research potential in pharmaceutical excipient formulation drug delivery system development and biomaterial engineering studies
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Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH) Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate Dimethyl malonate reduces neuronal apoptosis[1]
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